|
KMID : 0360320000320030524
|
|
Journal of Korean Cancer Research Association
2000 Volume.32 No. 3 p.524 ~ p.530
|
|
|
Combination Chemotherapy with Etoposide. Doxorubicin, Cisplatin (EAP) for Recurred or Metastatic Gastric Cancer Refractory to Prior Chemotherapy
|
|
Cho Nam-Kuk
Choi Tae-Sik
Park Yeon-Hee
Lee Seung-Chul
Yuh Young-Jin
Kim Sung-Rok
|
|
|
Abstract
|
|
|
Purpose :We performed this study to evaluated the efficacy and the safety of EAp regimen as second line therapy for the recurred or metastatic gastric cancer unresponsive to 5-fluorouracil base chemotherapy.
Materials and Methods : Recurred or metastatic gastric cancer patients unresponsive to 5-flurouracil based regimen were entered into this trial. They were treated by EAp chemotherapy which consisted of etoposide 40 mg/㎡, doxorubicin 15 mg/㎡, and cisplatin 25 mg/㎡ Ⅳ during 3 days each every 3 weeks.
Results : From December 1994 to March 1998, Eighteen patients were enrolled in this protocol. Fourteen patients were evaluable for response. The overall response rate was 28.6% (95% CI: 11.7∼ 56.7%). The median response duration was 21 weeks. The median survival for all enrolled patients was 28 weeks. The major toxicity was myelosuppression. Among total of 69 cycle chemotherapy. WHO grade 3 or 4 granulocytopenia and thrombocytopenia were observed in 71.0% and 27.5%, respectively.
Conclusion :Second line therapy with EAP regimen was active for gastric cancer. Chemotherapy induced toxicities were moderate to severe.
|
|
|
KEYWORD
|
|
|
Stomach neoplasm, Etoposide, Doxorubicin, Cisplatin, Chemotherapy,
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|